The Great Lizard-cuckoo (Coccyzus merlini) is a species of cuckoo in the Cuculidae family. The species is also known as the Cuban Lizard-cuckoo. It is found in Bahamas, Cuba, and Turks and Caicos Islands.

The Great Lizard-cuckoo is the largest of the lizard-cuckoos of the Caribbean and the largest species of Coccyzus cuckoo. It is 54 cm in length and weighs around 155 g. The plumage is similar to that of the other lizard-cuckoos, olive-brown backs, wings and crown, white throat and breast and chestnut belly with a deeply barred undertail. The eye has a patch of bare red skin around it, and the bill is long. The species feeds on lizards and insects such as locusts. Unlike some cuckoos it raises its own young, nesting in a saucer of twigs and laying 2-3 eggs.

Its natural habitats are subtropical or tropical dry forests, subtropical or tropical moist lowland forests, subtropical or tropical moist montane forest, and heavily degraded former forest.